{"id":5096,"date":"2019-01-21T09:37:53","date_gmt":"2019-01-21T08:37:53","guid":{"rendered":"http:\/\/sripzdravje-medicina.si\/?p=5096"},"modified":"2020-10-23T10:57:59","modified_gmt":"2020-10-23T08:57:59","slug":"reading-understanding-immune-system-switches-will-spark-new-drugs","status":"publish","type":"post","link":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/","title":{"rendered":"(Reading) Understanding immune system switches will spark new drugs"},"content":{"rendered":"<div class=\"field field-name-field-header field-type-text-long field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p class=\"selectionShareable\"><strong>Identifying the chemical switches that turn different parts of our immune system on and off is opening up new avenues for treating diseases such as Parkinson\u2019s, Alzheimer\u2019s, cancer and rheumatoid arthritis \u2013 and potential new uses for discarded drugs, according to Professor Luke O\u2019Neill, an immunologist at Trinity College Dublin, Ireland.<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"field field-name-body field-type-text-with-summary field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p class=\"selectionShareable\"><strong>Your work focuses on the innate immune system. Can you explain what this is?<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018In the past, scientists paid most attention to the adaptive immune system, which is the part that has antibodies that memorises invaders. Most of life on Earth does not have antibodies and defends itself with what we call the innate immune system. I\u2019ve been figuring out the component parts, like the way you\u2019d take apart a car engine. We didn\u2019t know what half the parts of the innate immune system even were. Now that we know more, we are creating drugs (that target this process) to help patients.\u2019<\/p>\n<p class=\"selectionShareable\"><strong>One of the effects of the innate immune system is inflammation. Why is this an important area of research?<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018The normal job of inflammation is to fix tissues. If you sprain your ankle and get an injury, inflammation is triggered to repair the wound.<\/p>\n<p class=\"selectionShareable\">\u2018What\u2019s amazing is that inflammation lies at the heart of so many diseases, when it gets out of control. That could be Alzheimer\u2019s in the brain, rheumatoid arthritis in joints, Crohn\u2019s disease in the gut or arteriosclerosis in the blood vessels. Steroids work for several of these diseases. Though steroids have side effects, this shows the diseases follow a common pathway. This gives us hope that if we can find specific pathways we could treat patients with different inflammatory disorders.\u2019<\/p>\n<p class=\"selectionShareable\"><strong>Can you give us an example of where this approach is showing promise?<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018A type of protein called Toll was discovered in fruit flies, and then versions were found throughout nature. We realised they were important more generally in the innate immune system of organisms, including in people. My lab looked at how (toll) receptors triggered macrophages (immune cells that attack bacteria and other invaders), and discovered a key switch called MAL. These discoveries provided new targets to fire drugs at.<\/p>\n<p class=\"selectionShareable\">\u2018My interest is mainly in inflammatory diseases like rheumatoid arthritis. The macrophages in rheumatoid arthritis patients somehow get reprogrammed to be overactive, for months on end. Blocking certain toll-like receptors could turn down inflammation and treat patients.&#8217;<\/p>\n<p class=\"selectionShareable\"><strong>What other examples of chemical switches there?<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018What\u2019s really exciting right now are checkpoint proteins, which were discovered a number of years ago. These are off-switches in the immune system to stop it running out of control. One is called PD1. A (cancer) tumour flicks the off switch, a cunning strategy to stop itself from being attacked. Now drug companies have developed a way to block that off-switch using checkpoint blockers. Once you do that, the cancer can be attacked by the immune system. We\u2019ve been studying these switches.\u2019<\/p>\n<p class=\"selectionShareable\"><strong>What\u2019s next?\u00a0<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018The brain has come into focus. We are more aware now that immune dysfunction is involved in diseases like Alzheimer\u2019s and Parkinson\u2019s disease, but also depression and, amazingly, schizophrenia too.<\/p>\n<p class=\"selectionShareable\">\u2018(We are) looking to block inflammasomes. These are switches on macrophages, which are frontline immune cells, that sense danger. If they detect something noxious, such as the beta-amyloid proteins in Alzheimer\u2019s, they drive inflammation. We could stop inflammation going into overdrive and perhaps get new medicines for Parkinson\u2019s and Alzheimer\u2019s. Wouldn\u2019t that be great?\u2019<\/p>\n<p class=\"selectionShareable\"><strong>Recently you happened upon a drug that had been tested and dropped, but you believe this drug can be used for patients?<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018Pfizer had discovered a compound, but dropped it for various reasons. We found that it blocks the NLRP3 inflammasome. The compound worked in models of multiple sclerosis, in sepsis, in Parkinson\u2019s disease and in Alzheimer\u2019s too. We were keen to take this further and we set up a company (in 2016) to do so, Inflazome.<\/p>\n<p class=\"selectionShareable\">\u2018There are lots of compounds on the shelf that drug companies could take down and dust off. Often they see side-effects and that puts them off, especially if they do not know how the compounds works.\u2019<\/p>\n<p class=\"selectionShareable\"><strong>You also worked on the MICROINNATE project which looked at RNA switches. Can you tell us about that?\u00a0<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018MicroRNAs were discovered about 15 years ago. These are small pieces of RNA that can stop cells making specific proteins. My lab was one of the first to discover their role in the innate immune response and we found that they were one of the key controllers in immunity. Efforts to use them as a therapeutic stalled initially, but there are now companies looking to use RNA as a drug.\u2019<\/p>\n<p class=\"selectionShareable\"><strong>You are a busy researcher, but you\u2019ve taken time to set up companies: why?<\/strong><\/p>\n<p class=\"selectionShareable\">\u2018As a scientist, your main passion is to make discoveries. If you do find something interesting, what do you do next? It\u2019s taxpayers\u2019 money funding research, so you have an obligation to exploit these discoveries or to pass it on to someone who will. One way is to form your own company. The biggest thrill is to help patients. That is always at the back of your mind. Imagine if your discovery, from noodling as I call it, makes a difference to people\u2019s lives.\u2019<\/p>\n<p class=\"selectionShareable\"><em>The MICROINNATE project was funded by the EU\u2019s European Research Council. If you liked this article, please share it on social media.<\/em><\/p>\n<p><a href=\"https:\/\/horizon-magazine.eu\/article\/understanding-immune-system-switches-will-spark-new-drugs.html\">Vir intervjuja<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Identifying the chemical switches that turn different parts of our immune system on and off is opening up new avenues for treating diseases such as Parkinson\u2019s, Alzheimer\u2019s, cancer and rheumatoid arthritis \u2013 and potential new uses for discarded drugs, according to Professor Luke O\u2019Neill, an immunologist at Trinity College Dublin, Ireland. Your work focuses on [&hellip;]<\/p>\n","protected":false},"author":47,"featured_media":5093,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[38],"tags":[],"class_list":["post-5096","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>(Reading) Understanding immune system switches will spark new drugs - SRIP Zdravje \u2013 medicina<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"(Reading) Understanding immune system switches will spark new drugs - SRIP Zdravje \u2013 medicina\" \/>\n<meta property=\"og:description\" content=\"Identifying the chemical switches that turn different parts of our immune system on and off is opening up new avenues for treating diseases such as Parkinson\u2019s, Alzheimer\u2019s, cancer and rheumatoid arthritis \u2013 and potential new uses for discarded drugs, according to Professor Luke O\u2019Neill, an immunologist at Trinity College Dublin, Ireland. Your work focuses on [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/\" \/>\n<meta property=\"og:site_name\" content=\"SRIP Zdravje \u2013 medicina\" \/>\n<meta property=\"article:published_time\" content=\"2019-01-21T08:37:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-23T08:57:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1400\" \/>\n\t<meta property=\"og:image:height\" content=\"954\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Visart\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Visart\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/\"},\"author\":{\"name\":\"Visart\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#\\\/schema\\\/person\\\/2c6c5490c12cd575ecb20017a2090381\"},\"headline\":\"(Reading) Understanding immune system switches will spark new drugs\",\"datePublished\":\"2019-01-21T08:37:53+00:00\",\"dateModified\":\"2020-10-23T08:57:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/\"},\"wordCount\":924,\"publisher\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Luke-ONeill-2018-b.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/\",\"url\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/\",\"name\":\"(Reading) Understanding immune system switches will spark new drugs - SRIP Zdravje \u2013 medicina\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Luke-ONeill-2018-b.jpg\",\"datePublished\":\"2019-01-21T08:37:53+00:00\",\"dateModified\":\"2020-10-23T08:57:59+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/#primaryimage\",\"url\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Luke-ONeill-2018-b.jpg\",\"contentUrl\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/wp-content\\\/uploads\\\/2019\\\/01\\\/Luke-ONeill-2018-b.jpg\",\"width\":1400,\"height\":954,\"caption\":\"NO FEE FOR 1ST REPRO Nobel Prize winners and world\u2019s brightest science minds ponder future of biology at Schr\u00f6dinger at 75 Chancellor of Trinity College Dublin, Dr Mary Robinson opened the Schr\u00f6dinger at 75 \u2013 the Future of Biology meeting, where Nobel Prize-winners and some of the world\u2019s brightest science minds are speaking this week. The meeting, organised by Trinity and hosted at Dublin\u2019s National Concert Hall, welcomes over 1,000 delegates to celebrate the 75th anniversary of Erwin Schr\u00f6dinger\u2019s game-changing \u2018What is life?\u2019 lectures, which were delivered in Trinity in 1943. Among the speakers who will share their thoughts on the burning issues of science today are Nobel Prize winners, Professors: Ada Yonath (Weizmann Institute of Science); Bernard Feringa (University of Groningen); John O\u2019Keeffe (University College London); Michael Rosbash (Brandeis University); Susumu Tonegawa (MIT). Pictured at the opening of the meeting, Chair of Biochemistry, Trinity College Dublin, Luke O\u2019Neill. Pic Paul Sharp\\\/SHARPPIX\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/2019\\\/01\\\/21\\\/reading-understanding-immune-system-switches-will-spark-new-drugs\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"(Reading) Understanding immune system switches will spark new drugs\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/\",\"name\":\"SRIP Zdravje \u2013 medicina\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#organization\",\"name\":\"SRIP Zdravje - medicina\",\"url\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/wp-content\\\/uploads\\\/2018\\\/08\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/wp-content\\\/uploads\\\/2018\\\/08\\\/logo.png\",\"width\":213,\"height\":150,\"caption\":\"SRIP Zdravje - medicina\"},\"image\":{\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/#\\\/schema\\\/person\\\/2c6c5490c12cd575ecb20017a2090381\",\"name\":\"Visart\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/0ef713a1e7e7e66d742fe5b7510ae930f3e04feeabe2514eb059c406c0db7ebe?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/0ef713a1e7e7e66d742fe5b7510ae930f3e04feeabe2514eb059c406c0db7ebe?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/0ef713a1e7e7e66d742fe5b7510ae930f3e04feeabe2514eb059c406c0db7ebe?s=96&d=mm&r=g\",\"caption\":\"Visart\"},\"url\":\"https:\\\/\\\/sripzdravje-medicina.si\\\/en\\\/author\\\/visart\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"(Reading) Understanding immune system switches will spark new drugs - SRIP Zdravje \u2013 medicina","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/","og_locale":"en_US","og_type":"article","og_title":"(Reading) Understanding immune system switches will spark new drugs - SRIP Zdravje \u2013 medicina","og_description":"Identifying the chemical switches that turn different parts of our immune system on and off is opening up new avenues for treating diseases such as Parkinson\u2019s, Alzheimer\u2019s, cancer and rheumatoid arthritis \u2013 and potential new uses for discarded drugs, according to Professor Luke O\u2019Neill, an immunologist at Trinity College Dublin, Ireland. Your work focuses on [&hellip;]","og_url":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/","og_site_name":"SRIP Zdravje \u2013 medicina","article_published_time":"2019-01-21T08:37:53+00:00","article_modified_time":"2020-10-23T08:57:59+00:00","og_image":[{"width":1400,"height":954,"url":"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg","type":"image\/jpeg"}],"author":"Visart","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Visart","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/#article","isPartOf":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/"},"author":{"name":"Visart","@id":"https:\/\/sripzdravje-medicina.si\/en\/#\/schema\/person\/2c6c5490c12cd575ecb20017a2090381"},"headline":"(Reading) Understanding immune system switches will spark new drugs","datePublished":"2019-01-21T08:37:53+00:00","dateModified":"2020-10-23T08:57:59+00:00","mainEntityOfPage":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/"},"wordCount":924,"publisher":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/#organization"},"image":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/#primaryimage"},"thumbnailUrl":"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/","url":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/","name":"(Reading) Understanding immune system switches will spark new drugs - SRIP Zdravje \u2013 medicina","isPartOf":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/#primaryimage"},"image":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/#primaryimage"},"thumbnailUrl":"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg","datePublished":"2019-01-21T08:37:53+00:00","dateModified":"2020-10-23T08:57:59+00:00","breadcrumb":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/#primaryimage","url":"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg","contentUrl":"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg","width":1400,"height":954,"caption":"NO FEE FOR 1ST REPRO Nobel Prize winners and world\u2019s brightest science minds ponder future of biology at Schr\u00f6dinger at 75 Chancellor of Trinity College Dublin, Dr Mary Robinson opened the Schr\u00f6dinger at 75 \u2013 the Future of Biology meeting, where Nobel Prize-winners and some of the world\u2019s brightest science minds are speaking this week. The meeting, organised by Trinity and hosted at Dublin\u2019s National Concert Hall, welcomes over 1,000 delegates to celebrate the 75th anniversary of Erwin Schr\u00f6dinger\u2019s game-changing \u2018What is life?\u2019 lectures, which were delivered in Trinity in 1943. Among the speakers who will share their thoughts on the burning issues of science today are Nobel Prize winners, Professors: Ada Yonath (Weizmann Institute of Science); Bernard Feringa (University of Groningen); John O\u2019Keeffe (University College London); Michael Rosbash (Brandeis University); Susumu Tonegawa (MIT). Pictured at the opening of the meeting, Chair of Biochemistry, Trinity College Dublin, Luke O\u2019Neill. Pic Paul Sharp\/SHARPPIX"},{"@type":"BreadcrumbList","@id":"https:\/\/sripzdravje-medicina.si\/en\/2019\/01\/21\/reading-understanding-immune-system-switches-will-spark-new-drugs\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sripzdravje-medicina.si\/en\/"},{"@type":"ListItem","position":2,"name":"(Reading) Understanding immune system switches will spark new drugs"}]},{"@type":"WebSite","@id":"https:\/\/sripzdravje-medicina.si\/en\/#website","url":"https:\/\/sripzdravje-medicina.si\/en\/","name":"SRIP Zdravje \u2013 medicina","description":"","publisher":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sripzdravje-medicina.si\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/sripzdravje-medicina.si\/en\/#organization","name":"SRIP Zdravje - medicina","url":"https:\/\/sripzdravje-medicina.si\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/sripzdravje-medicina.si\/en\/#\/schema\/logo\/image\/","url":"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2018\/08\/logo.png","contentUrl":"https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2018\/08\/logo.png","width":213,"height":150,"caption":"SRIP Zdravje - medicina"},"image":{"@id":"https:\/\/sripzdravje-medicina.si\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/sripzdravje-medicina.si\/en\/#\/schema\/person\/2c6c5490c12cd575ecb20017a2090381","name":"Visart","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/0ef713a1e7e7e66d742fe5b7510ae930f3e04feeabe2514eb059c406c0db7ebe?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/0ef713a1e7e7e66d742fe5b7510ae930f3e04feeabe2514eb059c406c0db7ebe?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/0ef713a1e7e7e66d742fe5b7510ae930f3e04feeabe2514eb059c406c0db7ebe?s=96&d=mm&r=g","caption":"Visart"},"url":"https:\/\/sripzdravje-medicina.si\/en\/author\/visart\/"}]}},"rttpg_featured_image_url":{"full":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1400,954,false],"landscape":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1400,954,false],"portraits":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1400,954,false],"thumbnail":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-150x150.jpg",150,150,true],"medium":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-300x204.jpg",300,204,true],"large":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-1024x698.jpg",1024,698,true],"1536x1536":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1400,954,false],"2048x2048":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1400,954,false],"ultp_layout_landscape_large":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1174,800,false],"ultp_layout_landscape":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",836,570,false],"ultp_layout_portrait":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",600,409,false],"ultp_layout_square":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",600,409,false],"et-pb-post-main-image":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-400x250.jpg",400,250,true],"et-pb-post-main-image-fullwidth":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-1080x675.jpg",1080,675,true],"et-pb-portfolio-image":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-400x284.jpg",400,284,true],"et-pb-portfolio-module-image":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-510x382.jpg",510,382,true],"et-pb-portfolio-image-single":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-1080x736.jpg",1080,736,true],"et-pb-gallery-module-image-portrait":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b-400x516.jpg",400,516,true],"et-pb-post-main-image-fullwidth-large":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1400,954,false],"et-pb-image--responsive--desktop":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1057,720,false],"et-pb-image--responsive--tablet":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",809,551,false],"et-pb-image--responsive--phone":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",396,270,false],"bdpp-medium":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",640,436,false],"rt_custom":["https:\/\/sripzdravje-medicina.si\/wp-content\/uploads\/2019\/01\/Luke-ONeill-2018-b.jpg",1400,954,false]},"rttpg_author":{"display_name":"Visart","author_link":"https:\/\/sripzdravje-medicina.si\/en\/author\/visart\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/sripzdravje-medicina.si\/en\/category\/news\/\" rel=\"category tag\">News<\/a>","rttpg_excerpt":"Identifying the chemical switches that turn different parts of our immune system on and off is opening up new avenues for treating diseases such as Parkinson\u2019s, Alzheimer\u2019s, cancer and rheumatoid arthritis \u2013 and potential new uses for discarded drugs, according to Professor Luke O\u2019Neill, an immunologist at Trinity College Dublin, Ireland. Your work focuses on&hellip;","_links":{"self":[{"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/posts\/5096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/users\/47"}],"replies":[{"embeddable":true,"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/comments?post=5096"}],"version-history":[{"count":1,"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/posts\/5096\/revisions"}],"predecessor-version":[{"id":5097,"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/posts\/5096\/revisions\/5097"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/media\/5093"}],"wp:attachment":[{"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/media?parent=5096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/categories?post=5096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sripzdravje-medicina.si\/en\/wp-json\/wp\/v2\/tags?post=5096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}